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目的探讨2型糖尿病(T2DM)患者空腹血清ghrelin与体成分、腹部脂肪分布、瘦素等的相关关系。方法检测40例初诊2型糖尿病患者的腰围、血压、血脂、血糖、空腹瘦素、胰岛素、ghrelin和HOMA-IR,生物电阻抗仪测体成分,螺旋CT测腹部脂肪分布,与35例健康人(对照组)进行比较,并做ghrelin与各指标间的相关性分析。结果 2型糖尿病患者的空腹血清ghrelin较正常人低(P<0.01);其与空腹血清瘦素水平呈正相关(r=0.431,P<0.05),与腹部内脏脂肪体积呈负相关(r=-0.782,P<0.01),与全身脂肪含量无显著相关性;女性血清ghre-lin水平较男性高(P=0.011)。结论 2型糖尿病患者的空腹血清ghrelin与腹部内脏脂肪体积呈负相关,提示ghrelin水平的降低可能与腹型肥胖、2型糖尿病有关。
Objective To investigate the relationship between fasting serum ghrelin and body composition, abdominal fat distribution and leptin in type 2 diabetes mellitus (T2DM). Methods The waist circumference, blood pressure, blood lipids, blood glucose, fasting leptin, insulin, ghrelin and HOMA-IR, bioelectrical impedance spectrometer and spiral CT were used to detect the distribution of abdominal fat in 40 newly diagnosed type 2 diabetic patients. (Control group) were compared, and do ghrelin correlation analysis between the indicators. Results The fasting serum ghrelin in type 2 diabetic patients was lower than that in normal subjects (P <0.01), and positively correlated with fasting serum leptin level (r = 0.431, P <0.05), negatively correlated with abdominal visceral fat volume (r = 0.782, P <0.01). There was no significant correlation between the level of serum total lipids and ghre-lin in women (P = 0.011). Conclusions Fasting serum ghrelin in type 2 diabetic patients is negatively correlated with abdominal visceral fat volume, suggesting that the reduction of ghrelin level may be related to abdominal obesity and type 2 diabetes.