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目的观察中心静脉导管胸腔置管引流的可行性及胸腔内注射高聚金葡素治疗恶性胸腔积液的疗效与不良反应的发生情况。方法采用中心静脉导管胸腔置管分次引流胸水至尽,1周内先后胸腔注射高聚金葡素3000U2次。结果36例恶性胸腔积液通过一次性穿刺置管引流,3d内有35例胸水排尽,成功率达97.2%。先后2次腔内注射高聚金葡素后,治疗恶性胸腔积液的有效率达77.8%(29/36)。腔内注药后有36%患者出现低热,无其他特别不良反应。结论①一次性中心静脉导管胸腔置管引流,操作简便、安全、痛苦小,且可留管胸腔反复引流;②高聚金葡素胸腔内注射治疗恶性胸腔积液疗效肯定,不良反应轻微。
Objective To observe the feasibility of catheterization and drainage of central venous catheter in thoracic cavity and the efficacy and adverse reactions of intrapleural injection of polyglutamine into malignant pleural effusion. Methods Central venous catheterization of pleural catheter drainage graded pleural effusion to do, within 1 week has pleural injection of 3000U 2 times high polymer. Results Thirty-six cases of malignant pleural effusion were drained through one-time puncture. Thirty-five cases of pleural effusion were drained in 3d, the success rate was 97.2%. Has 2 times after intraluminal injection of polyglutamine, the treatment of malignant pleural effusion, the effective rate of 77.8% (29/36). Thirty-six percent of patients developed intracavitary fever with low fever and no other adverse reactions. Conclusions ① Disposable central venous catheter is suitable for the treatment of malignant pleural effusion. It has the advantages of simple and safe operation, less pain and can be used for repeated drainage in the thoracic cavity.