多环芳烃(PAH)的结构与致癌性能间的关系,是涉及致癌机理研究的一个重大问题。五十年代,普尔曼等人曾提出著名的K区理论,虽然大致解释了当时的已知事实,但其预言与继后的实验则大多相矛盾。杰林纳等人,在米勒(Miller)等亲电致癌的理论基础 The relationship between the structure of polycyclic aromatic hydrocarbons (PAH) and carcinogenic properties is a major issue involving the study of carcinogenic mechanisms. In the fifties, Pullman et al. proposed the famous K-zone theory. Although it roughly explained the known facts of the time, its predictions were mostly in contradiction with subsequent experiments. Jelena et al., The theoretical basis of electrophilic carcinogenesis in Miller et al.