论文部分内容阅读
硅的职业性暴露可能导致肾小球及近球小管组织结构的改变。对有硅暴露的不吸烟工人进行尿铜、尿锌含量的检测 ,探讨其与肾组织学改变以及与工龄之间的关系。通过测定尿中微量白蛋白含量反映肾小球功能 ,测定尿中 α1-微球蛋白含量来判定近球小管重吸收功能 ,测定尿液中细胞内谷胱甘肽 S转移酶 ( GST)活性来判定近球小管结构的完整性。此外 ,还测定尿铜、锌和肌酐的含量。结果显示 ,硅暴露组与对照组比较发现 ,所有检测的指标均显著性升高。尿铜、锌含量与肾小球及近球小管结构和功能及工龄之间呈显著性相关。职业性硅暴露可能导致铜和锌以蛋白 -金属复合物的形式从尿中丢失 ,这些必需微量元素在尿中的含量可以作为检验肾功能失常与否的生物学标记。尿液 GST含量也许可以作为判定近球小管损伤的有用标志。
Occupational exposure to silicon may result in changes in the organization of glomeruli and proximal tubules. Urine copper and urinary zinc were detected in non-smoking exposed workers exposed to silicon, and their relationship with renal histological changes and their length of service were explored. Urine microalbumin content was measured to reflect glomerular function, urinary α1-microglobulin content to determine proximal tubular reabsorption, urine intracellular glutathione S-transferase (GST) activity to Determine the integrity of the structure of the proximal bulb. In addition, urinary copper, zinc and creatinine levels were also determined. The results showed that silicon exposure group compared with the control group found that all the indicators were significantly increased. Urinary copper, zinc content and glomerular and proximal tubule structure and function and length of service was significantly correlated. Occupational exposure to silicon may result in the loss of copper and zinc from the urine in the form of protein-metal complexes. The content of these essential trace elements in the urine may serve as a biomarker for testing for renal dysfunction. Urine GST content may be useful as a marker of proximal tubule damage.