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目的探讨妊娠糖尿病孕妇血栓前状态(PTS)标志物检测的临床意义。方法选取正常非妊娠女性45例(非妊娠组)、正常晚孕女性45例(正常妊娠组)及妊娠糖尿病女性45例(妊娠糖尿病组),检测其血浆血管性血友病因子(vWf)、P-选择素、凝血酶-抗凝血酶复合物(TAT)、纤维蛋白肽A(FPA)、蛋白C(PC)、血栓前体蛋白(TpP)、D-二聚体(D-dimer)含量。结果妊娠糖尿病(GMD)组与非妊娠组、正常妊娠组比较,GMD组血浆TpP、TAT、vWf、FPA、P-选择素、D-dimer均明显上升(P<0.05)。结论正常晚期妊娠女性具有PTS,妊娠糖尿病患者则具有较为显著PTS情况,所以糖尿病孕妇产前检测凝血和纤溶情况,可以及时发现病情,及时治疗,改善预后等。
Objective To investigate the clinical significance of detecting prethrombotic state (PTS) markers in pregnant women with gestational diabetes mellitus. Methods Forty five normal pregnant women (non-pregnant women), 45 normal pregnant women (normal pregnant women) and 45 pregnant women with gestational diabetes (gestational diabetes mellitus) were enrolled in this study. Their vWF, P-selectin, thrombin-antithrombin complex (TAT), fibrinopeptide A (FPA), protein C (PC), thrombus precursor protein (TpP), D-dimer content. Results Compared with normal pregnancy group, the levels of plasma TpP, TAT, vWf, FPA, P-selectin and D-dimer in gestational diabetes mellitus (GMD) group and non-pregnant group were significantly increased (P <0.05). Conclusion The women with normal late pregnancy have PTS and the patients with gestational diabetes have more significant PTS. Therefore, the prenatal diagnosis of coagulation and fibrinolysis in pregnant women with diabetes can detect the disease, timely treatment and improve the prognosis.