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目的:探讨甲胎蛋白异质体(AFP-L3)的检测对肝细胞肝癌(HCC)的诊断价值。方法:选取2009年2月至2012年11月在本院治疗的90例HCC患者为研究组,另选择同期接受治疗的慢性乙型肝炎患者30例和肝炎肝硬化患者30例作为对照组。观察三组患者的AFP、AFP-L3阳性率。结果:肝癌患者AFP和AFP-L3阳性率显著高于乙肝和肝硬化患者,差异具有统计学意义(P<0.05)。乙肝和肝硬化两组患者的AFP及AFP-L3阳性率无显著差异(P>0.05)。AFP>400 ng/m L:肝癌组AFP-L3阳性率显著高于乙肝组和肝硬化组,差异具有统计学意义(P<0.05)。结论:AFP-L3在HCC中的诊断价值较甲胎蛋白大,更适合在临床诊断中应用。
Objective: To investigate the diagnostic value of AFP-L3 in diagnosis of hepatocellular carcinoma (HCC). Methods: Totally 90 HCC patients treated in our hospital from February 2009 to November 2012 were enrolled in the study. Thirty patients with chronic hepatitis B and 30 patients with hepatitis cirrhosis were selected as the control group. Three groups of patients were observed AFP, AFP-L3 positive rate. Results: The positive rates of AFP and AFP-L3 in patients with hepatocellular carcinoma were significantly higher than those in patients with hepatitis B and cirrhosis (P <0.05). There were no significant differences in the positive rates of AFP and AFP between the two groups of patients with hepatitis B and cirrhosis (P> 0.05). AFP> 400 ng / m L: The positive rate of AFP-L3 in hepatocellular carcinoma was significantly higher than that in hepatitis B and cirrhosis (P <0.05). Conclusion: The diagnostic value of AFP-L3 in HCC is larger than that of alpha-fetoprotein, which is more suitable for clinical diagnosis.