论文部分内容阅读
目的：探讨促甲状腺素释放激素（ＴＲＨ）抗失血致低血容量性休克的作用和对呼吸频率（ＲＲ）、平均动脉压（ＭＡＰ）、血气参数及酸碱平衡紊乱的影响。方法：复制失血致低血容量性休克大鼠模型，观察ＴＲＨ治疗前、后及各组各时间点大鼠ＲＲ、ＭＡＰ、血气和酸碱平衡等各参数的变化。结果：ＴＲＨ组给药后ＭＡＰ即刻升高，５分钟ＭＡＰ达（１４．０±１．３）ｋＰａ（１ｋＰａ＝７．５ｍｍＨｇ），较低血容量性休克（ＨＳ）组增高３２％（ｔ＝２．５３１，Ｐ＜０．０５）；休克组大鼠在伤后３６０分钟ＭＡＰ仍较低，ＴＲＨ治疗组ＭＡＰ还比休克组高４２％（ｔ＝３．０１４，Ｐ＜０．０５）。休克组和ＴＲＨ治疗组失血后ＲＲ明显减慢，ＴＲＨ给药后５分钟ＲＲ升为（８０±９）次／ｍｉｎ，较休克组升高７８％（ｔ＝３．８９２，Ｐ＜０．０１）；伤后３６０分钟，ＴＲＨ组ＲＲ达（９９±９）次／ｍｉｎ，比休克组高７１％（ｔ＝３．４５６，Ｐ＜０．０１）。ＴＲＨ降低了肺体指数和肺含水率；升高ｐＨ、ＨＣＯ－３，改善酸中毒和酸碱失衡。结论：ＴＲＨ在失血致低血容量性休克治疗过程中有重要作用，能有效减轻休克的严重程度。
Objective: To investigate the effects of thyrotropin releasing hormone (TRH) on hypovolemic shock induced by hemorrhagic shock and its effects on respiratory rate (RR), mean arterial pressure (MAP), blood gas parameters and acid-base balance disorders. Methods: The hemorrhagic shock model of hypovolemic shock was duplicated and the changes of RR, MAP, blood gas and acid-base balance in rats before and after TRH treatment were observed. Results: The MAP immediately after the administration of TRH in the TRH group was (14.0 ± 1.3) kPa (1kPa = 7.5mmHg) in 5 minutes and 32% in the hypovolemic shock group (t = 2.531, P <0.05). The MAP in shock rats was still lower at 360 minutes and the MAP in TRH treatment group was 42% higher than that in shock group (t = 3.014, P <0.05). RR in shock group and TRH treatment group decreased significantly after hemorrhage, RR increased to (80 ± 9) min / min at 5 min after TRH administration, and increased 78% compared with shock group (t = 3.892, P <0.01 ). At 360 minutes after injury, the RR of TRH was (99 ± 9) times / min in TRH group, which was 71% higher than that in shock group (t = 3.456, P <0.01). TRH decreased lung index and lung water content; increased pH, HCO-3, to improve acidosis and acid-base imbalance. Conclusion: TRH plays an important role in the treatment of hemorrhagic shock due to hypovolemia, which can effectively reduce the severity of shock.