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目的：观察脑供血不足病人采用地尔硫静脉注射后对脑血流有否即刻效应。方法：经颅多普勒超声（ＴＣＤ）诊断的脑供血不足病人３０例（男性１８例，女性１２例；年龄６５ａ±ｓ１０ａ）给地尔硫针剂１０ｍｇ加入２５％葡萄糖注射液２０ｍＬ中静脉缓慢推注（８ｍｉｎ注射完毕），注射后１０ｍｉｎ再复查ＴＣＤ。结果：用药１０ｍｉｎ后血压下降、心率减慢差别均有非常显著意义（Ｐ＜０．０１）；２４例（８０％）病人脑血流有明显增快（增幅≥２ｃｍ／ｓ），６例（２０％）病人脑血流稍有增快（增幅＜２ｃｍ／ｓ），其中对脑动脉的收缩期血流速度和平均血流速度的改善有显著意义（分别为Ｐ＜０．０１，Ｐ＜０．０５）。结果：地尔硫静脉注射对脑动脉供血不足有显著的即刻效应。
OBJECTIVE: To observe whether there is an immediate effect on cerebral blood flow after intravenous injection of diltiazem in patients with cerebral insufficiency. Methods: Thirty patients (18 males and 12 females; age 65a ± s10a) diagnosed by transcranial Doppler ultrasonography (TCD) were given diltiazem 10mg into a 20mL medium vein of 25% glucose injection Bolus injection (8min injection completed), 10min after injection and then review the TCD. Results: After 10 minutes of treatment, the blood pressure decreased and heart rate decreased significantly (P <0.01). In 24 cases (80%), the cerebral blood flow was significantly increased (≥2 cm / s) 20%) had a slight increase in cerebral blood flow (<2 cm / s), which had significant effects on the improvement of systolic and mean velocity of cerebral blood flow (P <0.01 and P < 0.05). Results: Diltiazem intravenous injection of cerebral arterial insufficiency has a significant immediate effect.