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据研究表明纳络酮可阻滞可乐定在原发性高血压大鼠中的抗高血压效应,但对其在正常血压的大鼠或正常人体中的心血管效应无拮抗作用。有关纳络酮在高血压患者中可能拮抗可乐定的作用已进行研究。 6名应用可乐定的高血压患者随机分为2组。受试者静脉滴注共8小时。第一组输注含纳络酮
Naloxone has been shown to block the antihypertensive effects of clonidine in primary hypertensive rats but has no antagonism of its cardiovascular effects in normotensive rats or normal humans. The role of naloxone in antagonizing clonidine in hypertensive patients has been studied. Six patients with clonidine hypertension were randomly divided into two groups. Subjects were infused intravenously for 8 hours. The first group contains naloxone