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合成并表征了三个钌(II)多吡啶配合物[Ru(phen)2(7-CH3-dppz)]2+(i)、[Ru(phen)2(7-F-dppz)]2+(ii)和[Ru(phen)2(7-CF3-dppz)]2+(iii).利用光谱法和粘度实验研究了配合物与DNA的结合行为.结果表明3个配合物均以插入方式与DNA结合,其与DNA的亲和力顺序为(ii)>(i)>(iii).同时采用密度泛函(DFT)理论计算合理解释了3个配合物与DNA结合行为的差异.
Three complexes of Ru (phen) 2 (7-CH3-dppz)] 2+ [Ru (phen) 2 (7-F-dppz)] 2+ (Ⅱ) and [Ru (phen) 2 (7-CF3-dppz)] 2+ (iii). The binding properties of the complexes with DNA were studied by spectroscopy and viscosity experiments. The results showed that all three complexes were inserted DNA binding affinity sequence with DNA (ii)> (i)> (iii). At the same time using density functional theory (DFT) theoretical calculations to explain the three complexes and DNA binding behavior differences.