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目的：通过２８例子宫恶性苗勒氏管混合瘤的临床资料，探讨相关因素及适当的治疗方法。方法：回顾性分析１９７２年１月－１９９７年 １２月我院收治的 ２８例子宫恶性苗勒氏管混合瘤的临床资料。结果：５年总生存率３５．７％。癌肉瘤 ５年生存率４１．７％，中胚叶混合瘤５年生存率３１．３０（Ｐ＞０．０５）。Ⅰ、Ⅱ期患者５年生存率５６．３％，明显高于Ⅲ、Ⅳ期的９．１％（Ｐ＜０．０１）。子宫体积大于妊娠 １０周者， ５年生存率 ０％，小于 １０周者， ５年生存率 ５３ ．０％（ Ｐ＜ ０． ０１）。已绝经组 ５年生存率 ３８ ．９％，高于未绝经组３０％（Ｐ＞０．０５）。应用 Ｃｏｘ模型比较术后加放疗或化疗对生存率的影响，放疗组明显高于化疗组，Ｐ＜０．０１。表明化疗可提高患者生存率。结论：子宫恶性苗勒氏管混合瘤生存率与手术病理分期、子宫大小有密切关系，与病理类型、是否绝经无明显关系，术后辅以放疗对提高生存率有帮助。
Objective: To investigate the related factors and the appropriate treatment methods through the clinical data of 28 cases of malignant Müllerian mixed tumor. Methods: A retrospective analysis of January 1972 - December 1997 admitted to our hospital in 28 cases of uterine malignant Mullerian mixed tumor clinical data. Results: The 5-year overall survival rate was 35.7%. The 5-year survival rate of carcinomatous sarcoma was 41.7%, and the 5-year survival rate of mixed mesodermal tumor was 31.30 (P> 0.05). The 5-year survival rates of stage Ⅰ and stage Ⅱ patients were 56.3%, significantly higher than those of stage Ⅲ and Ⅳ (P <0.01). Uterine volume greater than 10 weeks of pregnancy, 5-year survival rate of 0%, less than 10 weeks, 5-year survival rate of 53. 0% (P <0.01). 5-year survival rate of the menopause group 38. 9%, higher than 30% of non-menopause group (P> 0.05). The Cox model was used to compare the effect of postoperative radiotherapy and chemotherapy on the survival rate. The radiotherapy group was significantly higher than the chemotherapy group (P <0.01). Chemotherapy can improve patient survival. Conclusions: The survival rate of malignant Miele ’s canal mixed tumor is closely related to the pathological stage and uterine size of the uterus. It is not related to the pathological type and whether it is menopause. Postoperative radiotherapy is helpful to improve the survival rate.