论文部分内容阅读
Ⅰ型糖尿病(IDDM)的发病机制至今未明,一般认为与遗传、环境因素及病毒感染等有关。近期许多研究表明,Ⅰ型糖尿病属器官特异性自身免疫性疾病,在导致胰岛β细胞破坏的最初阶段,病毒感染是重要原因之一。Clements报告柯萨奇病毒感染可引起胰岛细胞白身免疫而致IDD。柯萨奇病毒为小RNA病毒科肠道病毒属的成员,分A、B两组。A组包括1～24型,B组包括1～6型。基因组为学单链正股RNA。我们对糖尿病患者进行了柯萨奇B_(1-6)特异性IgM检测,以探讨柯萨奇B组病毒感染在IDDM发病中的作用。
The pathogenesis of type 1 diabetes mellitus (IDDM) is still unknown. It is generally considered to be related to genetic and environmental factors as well as viral infections. Recently, many studies have shown that type I diabetes is an organ-specific autoimmune disease and viral infection is one of the important reasons in the initial stage of pancreatic islet β-cell destruction. Clements reports that Coxsackie virus infection causes idiopathic immune cells that cause IDD. Coxsackie virus is a member of the small RNA virus family Enterovirus, sub-A, B two groups. Group A includes type 1 to 24, and group B includes type 1 to type 6. The genome is a single-strand strand RNA. We conducted a coxsackie B_ (1-6) specific IgM test in diabetic patients to investigate the role of coxsackie B virus infection in the pathogenesis of IDDM.