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目的:研究模拟胃肠道系统酶解对地龙膜分离后活性部位纤溶、降压作用的影响。方法:对酶解前后新鲜红地龙的匀浆液采用不同孔径的聚偏氟乙烯膜进行超滤,对超滤液进行纤溶和血管紧张素转换酶(ACE)抑制活性的测定。结果:酶解后匀浆液的纤溶活性总体基本没有改变,但分子量大的部位纤溶活性下降,而分子量小的部位则上升;ACE抑制活性随着酶解得到提高,以4千膜的滤过液为最。结论:消化道酶解不会降低地龙的纤溶活性,地龙匀浆后以分子量为1万的膜进行截留,可得到纤溶活性更强的部位;地龙的降压作用经过胃肠道的酶解会得到增强,先行酶解会有益于降压作用的提高。
Objective: To study the effects of gastrointestinal system enzymolysis on fibrinolysis and antihypertensive effect of active site after Dilong membrane separation. Methods: Ultrafiltration was performed on the homogenates of fresh red loons before and after enzymatic hydrolysis using polyvinylidene fluoride (PVDF) membranes with different pore diameters. The fibrinolytic and angiotensin converting enzyme (ACE) inhibitory activities of the ultrafiltrates were determined. Results: The fibrinolytic activity of the homogenate did not change basically after enzymolysis, but the fibrinolytic activity decreased at the larger molecular weight and increased at the smaller molecular weight. The ACE inhibitory activity increased with enzymolysis, The most. CONCLUSION: Digestive tract enzymolysis does not decrease the fibrinolytic activity of earthworm. After the earthworm homogenate, it can be intercepted by the membrane with a molecular weight of 10000, and the more fibrinolytic activity can be obtained. The antihypertensive effect of earthworm through the gastrointestinal Road, enzymatic hydrolysis will be enhanced, the first enzymatic hydrolysis will help improve the antihypertensive effect.