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目的探讨新疆地区部分2型糖尿病(T2DM)患者体脂分布特点与心血管危险因素之间的关系。方法用Inbody720人体成分分析仪对155例T2DM患者行腹部内脏脂肪面积(VA)、体脂百分比(PBF)测量,同时测量空腹三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、收缩压(SBP)、舒张压(DBP)、糖化血红蛋白(HbA1c)、体质量(W)、身高(H)、腰围(WC)、臀围(HC),计算体质量指数(BMI)、腰臀比(WHR)。对体脂参数与代谢危险因素行Pearson相关分析及多元逐步回归分析。结果无论男女,腹部内脏型肥胖(VFO)的BMI水平高于腹部皮下型肥胖(SFO),男性VFO的TG水平高于SFO。女性患者PBF、TC及LDL-C显著高于男性患者。少数民族男性患者VA、PBF显著高于汉族男性。在校正年龄、病程、BMI后,女性患者WHR与DBP呈正相关,PBF与LDL-C呈正相关。男性患者的BMI与SBP、VA与DBP、VA与PBF和HDL-C有关联;女性患者的BMI与SBP、WHR与DBP有关联。结论 T2DM患者体脂分布均以腹型肥胖为主,尤其是以VFO为特点,其心血管危险因素不仅与体脂水平增加有关,更与VFO有关,且存在性别、族别差异。
Objective To investigate the relationship between body fat distribution and cardiovascular risk factors in some type 2 diabetes mellitus (T2DM) patients in Xinjiang region. Methods The abdominal visceral fat area (VA) and body fat percentage (PBF) were measured in 155 T2DM patients with Inbody 720 body composition analyzer. The levels of fasting triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP), glycosylated hemoglobin (HbA1c), body weight (W), height (H) , Hip circumference (HC), body mass index (BMI) and waist-to-hip ratio (WHR). Pearson correlation analysis and multiple stepwise regression analysis of body fat parameters and metabolic risk factors. Results Both men and women had higher BMI in abdominal visceral obesity (VFO) than in abdominal subcutaneous obesity (SFO) and TG in male VFO was higher than in SFO. Female patients PBF, TC and LDL-C was significantly higher than male patients. Minority male patients with VA, PBF was significantly higher than Han men. After adjusting for age, course of disease and BMI, female patients had a positive correlation between WHR and DBP, and a positive correlation between PBF and LDL-C. BMI in male patients was associated with SBP, VA and DBP, VA and PBF and HDL-C; BMI in female patients was associated with SBP, WHR and DBP. Conclusion The body fat distribution of T2DM patients is mainly abdominal obesity, especially VFO. The cardiovascular risk factors are related not only to the increase of body fat but also to VFO, and there are differences in sex and ethnicity.