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目的探讨血清蛋白电泳谱变化对肝脏疾病诊断及治疗的临床意义。方法将180例患者按临床诊断分为三组即病毒性肝炎组、肝硬化组、肝癌组与正常对照组进行血清蛋白电泳检测及分析。结果病毒性肝炎患者ALB、α2、β球蛋白降低,γ球蛋白升高。肝硬化患者除γ球蛋白显著升高外其余组分均降低。肝癌患者α1、α2和γ球蛋白显著升高,其余组分均降低。结论血清蛋白电泳能全面的反映肝脏疾病时蛋白质各个组分的变化,对于肝病的诊断、鉴别诊断、病情发展的判断有重要的意义。
Objective To investigate the clinical significance of serum protein electrophoresis changes in the diagnosis and treatment of liver diseases. Methods According to clinical diagnosis, 180 patients were divided into three groups: viral hepatitis group, cirrhosis group, liver cancer group and normal control group for detection and analysis of serum protein electrophoresis. Results In patients with viral hepatitis, the levels of ALB, α2, β-globulin and γ-globulin increased. Patients with cirrhosis except γ-globulin increased significantly except for the rest of the components. Α1, α2 and γ-globulin in patients with liver cancer were significantly increased, the remaining components were reduced. Conclusion Serum protein electrophoresis can fully reflect the changes of various components of proteins in liver diseases, which is of great significance for diagnosis, differential diagnosis and judgment of disease development.