[与肿瘤反应的抗体及毒素的交联物(免疫毒素)已被用于在体外及体内清除肿瘤细胞。这样的免疫毒素用于杀伤受侵润的骨髓中的小鼠白血病细胞颇为有效,因此在采用骨髓挽救途径治疗癌症方面应有其价值。注射原类似的免疫毒素可导致小鼠白血病的长期缓解,含抗原的免疫毒素则可在体外引起正常小鼠睥细胞的免疫无反应。因此采用免疫毒素的长期目标应包括体内杀伤癌细胞及调变免疫反应以达治疗目的。] [Tumor-reactive cross-linked antibodies and toxins (immunotoxins) have been used to clear tumor cells in vitro and in vivo. Such immunotoxins are quite effective in killing mouse leukemia cells in infiltrated bone marrow and should therefore be of value in the treatment of cancer using the bone marrow rescue route. Injection of similar immunotoxins leads to long-term relief of leukemia in mice, while immunotoxins containing antigens can cause immune non-responsiveness in normal mouse gallbladder cells in vitro. Therefore, the long-term goal of using immunotoxins should include in vivo killing of cancer cells and modulation of immune responses for therapeutic purposes. ]