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已从芍药根中分离出许多类单萜类化合物,芍药甙(PF)是其中之一。PF具有降低血压、扩张血管以及松弛和抑制平滑肌运动和强直性痉挛等药理作用。作者曾报道PF经人肠道细菌作用后,能产生三种芍药代谢物Ⅰ～Ⅲ(PMI-Ⅲ),并发现主要的代谢物PM-Ⅰ对动物的抗惊厥作用强于PF。PM-Ⅰ是(7R)-和(7S)-异构体的混合物,本文报道了用酶免疫测定法(EIA)定量测定PM-Ⅰ。 乳杆菌菌液以37℃厌氧培养12h后,经
Many types of monoterpenoids have been isolated from the roots of Paeonia lactiflora. One of these is PF. PF has the pharmacological effects of lowering blood pressure, dilating blood vessels, and relaxing and inhibiting smooth muscle movement and tonic spasm. The authors have reported that PF can produce three kinds of peony metabolites I-III (PMI-III) after the action of human intestinal bacteria, and found that the main metabolite PM-I has stronger anticonvulsant effects on animals than PF. PM-I is a mixture of (7R)- and (7S)-isomers, and it was reported herein that PM-I was quantified using an enzyme immunoassay (EIA). The Lactobacillus broth was anaerobicly incubated at 37°C for 12 hours.