新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)是新生儿期死亡及儿童伤残的主要原因之一。据统计,我国每年活产婴儿1800万~2000万,新生儿HIE的发生率约为活产儿的3‰~6‰,其中15%~20%在新生儿期死亡,存活者中25%~30%可能留有不同类型和程度的远期后遗症,成为危害我国儿童生存质量的重要疾病之一[1]。因 Hypoxic-ischemic encephalopathy (HIE) is one of the main causes of neonatal death and child disability. According to statistics, China’s annual live birth of 18 million to 20 million infants, the incidence of neonatal HIE about live births 3 ‰ ~ 6 ‰, of which 15% to 20% died in neonatal period, survivors, 25% to 30 % May leave different types and degrees of long-term sequelae and become one of the important diseases that endanger the quality of children’s life in our country. [1] because