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目的：探讨nm23和增殖细胞核抗原（PCNA）与鼻咽癌生物学行为的相互关系。方法：用免疫组织化学法对87例鼻咽癌（NPC）患者的癌组织及癌旁组织进行nm23／NDPK（二磷酸核苷激酶）和PCNA检测。结果：nm23的阳性表达率鼻咽癌组织比癌套组织低（P＜0.05），而PCNA（Ⅱ级以上）的表达率则比癌旁组织显著增高（P＜0．01）；并且随着肿瘤浸润生长（T分级升高），癌组织nm23的表达下降（P＜0.01），PCNA表达则上升(P＜0．01）；颈淋巴转移与该二项标志物表达无显著相关（P＞005）。结论：nm23和PCNA均能很好反映鼻咽癌的增殖活性，呈相互拮抗趋势，可成为预测鼻咽癌局部转归的依据和指导临床治疗的指标。
Objective: To investigate the relationship between nm23, proliferating cell nuclear antigen (PCNA) and biological behavior of nasopharyngeal carcinoma. Methods: nm23 / NDPK (nucleoside diphosphate kinase) and PCNA were detected by immunohistochemical staining in 87 cases of NPC and its adjacent tissues. Results: The positive expression rate of nm23 in nasopharyngeal carcinoma tissues was lower than that in carcinoma tissues (P <0.05), while the expression of PCNA (grade Ⅱ or higher) was significantly higher than that in paracancer tissues (P <0.01) (P <0.01), while the expression of PCNA increased (P <0.01). There was no significant correlation between cervical lymph node metastasis and the expression of these two markers (P> 005). CONCLUSION: Both nm23 and PCNA can well reflect the proliferative activity of nasopharyngeal carcinoma and show a tendency of mutual antagonism. It may be used as a basis to predict the local outcome of nasopharyngeal carcinoma and guide the clinical treatment.