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目的探讨糖尿病(DM)大鼠发病早期认知功能障碍的发病机制及褪黑素(Mel)对其保护作用。方法将DM大鼠分成DM组和Mel干预组,研究其认知功能变化,测定海马组织和血浆中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)和丙二醛(MDA)水平,观察海马组织的超微结构。结果 DM大鼠发病8周时出现认知功能障碍,高剂量Mel组大鼠逃避潜伏期,游出距离降低,探索实验中Platform%升高,海马组织和血浆MDA降低,GSH-Px、SOD升高(P均<0.01),Mel可以部分改善其海马组织的超微结构。结论褪黑素可改善糖尿病大鼠认知功能障碍,其保护作用可能是通过抗氧化应激实现的。
Objective To investigate the pathogenesis of cognitive dysfunction and the protective effect of melatonin (Mel) in the early onset of diabetic rats. Methods DM rats were divided into two groups: DM group and Mel group. The changes of cognitive function were studied. The levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) Aldehyde (MDA) levels were observed ultrastructural changes in the hippocampus. Results The cognitive dysfunction occurred in DM rats at 8 weeks. The escape latency and travel distance of rats in high-dose Mel group were lower than those in high-dose Mel group. The increase of Platform%, the decrease of MDA and the increase of GSH-Px and SOD in hippocampus tissue and plasma (All P <0.01). Mel can partially improve the ultrastructure of hippocampal tissue. Conclusion Melatonin can improve cognitive dysfunction in diabetic rats, and its protective effect may be through anti-oxidative stress.