论文部分内容阅读
目的探讨丹参多酚酸盐对急性冠脉综合征(ACS)患者血小板活化功能的影响及作用机制。方法选取123例ACS患者分为观察组(60例)和对照组(63例),均实施常规基础治疗,观察组另给予丹参多酚酸盐辅助治疗,对照组给予等量生理盐水安慰剂。对比两组临床疗效。结果观察组总有效率(88.33%)和对照组(68.25%)差异有统计学意义(P<0.05);治疗前观察组CD63、CD62p和GP IIb/IIIa和对照组比较差异无统计学意义(P>0.05),治疗后观察组降低程度和对照组差异有统计学意义(P<0.05);观察组不良心血管事件发生率(3.33%)和对照组(4.76%)差异无统计学意义(P>0.05)。结论丹参多酚酸盐可以显著改善ACS患者血小板活化功能,推测可能和CD63、CD62p和GP IIb/IIIa蛋白水平有关。
Objective To investigate the effect and mechanism of salvianolate on platelet activation in patients with acute coronary syndrome (ACS). Methods A total of 123 patients with ACS were divided into observation group (60 cases) and control group (63 cases). All patients underwent routine basic treatment. Salviae miltiorrhizae was additionally given in the observation group and saline control placebo was given in the control group. Compare two groups of clinical curative effect. Results The total effective rate (88.33%) in the observation group and the control group (68.25%) had statistical significance (P <0.05). There was no significant difference between the observation group before treatment and the control group (CD63, CD62p and GP IIb / P> 0.05). There was significant difference between the observation group and the control group after treatment (P <0.05). The incidence of adverse cardiovascular events (3.33%) and the control group (4.76%) had no significant difference P> 0.05). Conclusion salvianolate can significantly improve platelet activation in patients with ACS, presumably with CD63, CD62p and GP IIb / IIIa protein levels.