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目的研究非去极化肌松药罗库溴铵和顺式阿曲库铵对分娩期SD大鼠离体子宫平滑肌收缩功能的影响。方法脱颈椎法处死分娩期SD大鼠,取子宫平滑肌组织,放置离体实验装置中,浴槽中给予去极化肌松药,通过换能器转换,将平滑肌收缩情况记录于多道生理信号分析仪;然后分别用缩宫素和肌松药拮抗剂新斯的明作用于平滑肌,并分别记录收缩值。数据采用SPSS 17.0处理,SigmaPlot作图,比较药物作用下平滑肌收缩抑制情况。结果罗库溴铵和顺式阿曲库铵对分娩期SD大鼠离体子宫平滑肌收缩具有抑制作用(P<0.05),罗库溴铵和顺式阿曲库铵组间差异无统计学意义;加入缩宫素和新斯的明后,被抑制的平滑肌收缩力增强(P<0.05)。结论罗库溴铵和顺式阿曲库铵对分娩期SD大鼠离体子宫平滑肌收缩功能可产生抑制作用,缩宫素和新斯的明可缓解非去极化肌松药对离体子宫平滑肌的收缩抑制。
Objective To study the effects of nondepolarizing muscle relaxants rocuronium and cisatracurium on contractile function of isolated uterine smooth muscles in SD rats during labor. Methods Sprague-Dawley rats were sacrificed and the uterine smooth muscle tissue was taken from the uterine smooth muscle. The depolarized muscle relaxants were placed in the bath. The contraction of the smooth muscle was recorded by multi-channel physiological signal analysis Instrument; and then respectively oxytocin and muscle relaxant antagonist neostigmine effect on the smooth muscle, and were recorded contraction value. The data were processed by SPSS 17.0 and plotted by SigmaPlot to compare the inhibition of smooth muscle contraction under the action of drugs. Results Rocuronium and cisatracurium inhibited the contraction of isolated uterine smooth muscle in SD rats during delivery (P <0.05), but there was no significant difference between Rocuronium and cisatracurium groups. After oxytocin and neostigmine, contractile smooth muscle contractility was enhanced (P <0.05). Conclusion Rocuronium and cisatracurium can inhibit the contractile function of isolated uterine smooth muscle in SD rats during delivery. Oxytocin and neostigmine can relieve the effects of non-depolarizing muscle relaxants on isolated uterine smooth muscle Inhibition of contraction.