慢性砷中毒是一种地球化学性疾病,可能导致皮肤损伤、心血管疾病、免疫损伤、糖尿病和癌症等,但砷的毒作用机制目前尚不清楚。代谢组学是系统生物学的组成部分,旨在对生物体内所有代谢物(多数是相对分子质量≤1 000的小分子物质)进行定性和定量分析,了解内外因作用下生物体内源性物质变化及规律。代谢组学从微观角度研究生物代谢和表型以及生物功能变化间关系,对研究生理状态、发现生物标志物和诊断疾病具有重要作用。本文就应用代谢组学技术研究砷暴露对柠檬酸和胆碱循环及氨基酸和脂肪酸代谢的影响予以综述。 Chronic arsenic poisoning is a geochemical disease that can cause skin damage, cardiovascular disease, immune damage, diabetes and cancer, but the mechanism of arsenic toxicity is not yet clear. Metabolomics is an integral part of systems biology. It aims to conduct qualitative and quantitative analysis of all metabolites in organisms (mostly small molecules with molecular weights less than 1,000), to understand the changes of endogenous and exogenous substances in organisms And the law. Metabolomics studies the relationship between biological metabolism and phenotypic and biological function changes from a microscopic point of view, and plays an important role in studying physiological status, finding biomarkers and diagnosing diseases. This review summarizes the effects of arsenic exposure on citric acid and choline circulation and the metabolism of amino acids and fatty acids using metabolomics techniques.