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作者观察了5例癫痫患者因大量苯妥英钠中毒而引起的眼球运动障碍,其中2例约各服30片(每片100毫克),另3例由静脉输入,分别在800至2000毫克之间。在观察期间或期前未接受其它抗痉挛剂或中枢神经系统抑制剂。皆无外听道阻塞,听力试验排除了中耳或第8对颅神经周围性疾病。血苯妥英钠值由气体—液体色层分离法测定。所有患者在苯妥英钠引起的临床状态消散后,神经系统检查无明显异常。全组5例在摄入大量苯妥英钠后均引起完全性
The authors observed eye movement disorders in 5 patients with epilepsy due to a large number of phenytoin sodium poisoning, of which about 2 in about 2 servings (100 mg each) and 3 in intravenous infusions of 800 to 2000 mg, respectively. No other anticonvulsants or CNS inhibitors were taken during or before the observation period. No external auditory canal obstruction, hearing test excluded the middle ear or 8 cranial nerve peripheral diseases. Blood sodium phenytoin was determined by gas-liquid chromatography. All patients after phenytoin-induced clinical status dissipated, no significant abnormal neurological examination. The whole group of 5 patients all caused completeness after ingesting a large amount of phenytoin sodium