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在体外培养的肾透明细胞癌系中,观察了异搏定(Verapamil,VP)对5-氟脲嘧啶(Fluorouracil,5-Fu)细胞毒作用的影响。结果表明,异搏定在本身无细胞毒性的浓度下,可以显著增强5-氟脲嘧啶的细胞毒性,且增效作用随5-氟脲嘧啶浓度及异搏定浓度的增加及用药时间的延长而增强。
The effect of Verapamil (VP) on the cytotoxicity of 5-fluorouracil (5-Fu) was observed in cultured renal clear cell carcinoma. The results showed that verapamil at its own non-cytotoxic concentrations can significantly enhance the cytotoxicity of 5-fluorouracil, and the synergistic effect with the 5-fluorouracil concentration and verapamil concentration and drug treatment time extension And enhanced.