目的了解艾滋病感染者和患者配偶的艾滋病感染率和抗体阳转率等,为制定有针对性的防控措施提供依据。方法对409名艾滋病感染者和患者的配偶进行基线调查,收集社会人口学资料、艾滋病相关知识、性行为等信息,采血检测HIV抗体,并进行宣教咨询、发放安全套等干预。半年后对138名基线调查中HIV抗体检测为阴性的配偶进行随访调查。结果基线时调查对象艾滋病知识知晓率为69.9%;80.3%最近半年与配偶发生过性行为,50.2%未每次使用安全套;艾滋病抗体检测阳性率为34.7%。随访时调查对象的艾滋病知识知晓率上升为98.6%;84.1%最近半年与配偶发生过性行为,其中仅有2名随访调查对象未每次使用安全套;138名随访调查对象HIV抗体阳转率为0.7%。结论宣传干预与随访管理,在预防艾滋病经婚内性途径传播起着积极的作用,同时要加强单阳配偶抗病毒治疗,以降低配偶间传播的风险。 Objective To understand the HIV infection rate and antibody positive rate among spouses of AIDS-infected persons and patients, and provide the basis for the development of targeted prevention and control measures. Methods A total of 409 HIV / AIDS patients and their spouses were investigated by baseline survey. Demographic demographic data, HIV / AIDS related knowledge, and sexual behaviors were collected. Blood samples were collected for HIV antibody testing, counseling and condom distribution. Six months later, 138 spouses who were negative for HIV antibody test in the baseline survey were followed up. Results The awareness rate of AIDS knowledge was 69.9% at baseline; 80.3% had sexual intercourse with spouse in the last six months, while 50.2% did not use condom every time. The positive rate of AIDS antibody test was 34.7%. During follow-up, the awareness of AIDS among the surveyed subjects increased to 98.6%; 84.1% had sexual intercourse with their spouse in the recent six months, of whom only 2 did not use condoms at each follow-up; and the rate of HIV antibody positive in 138 follow-up subjects was 0.7%. Conclusion Publicity intervention and follow-up management play a positive role in preventing the spread of AIDS through the sexual intercourse of marriage. At the same time, we should strengthen the treatment of single-Yang spouse antiviral therapy to reduce the risk of spousal transmission.