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[目的]比较中晚期食管癌采用单纯放射治疗与放疗同时合并动脉灌注化疗的临床反应、疗效及生存期。[方法]对36例经胃境及病理证实的中晚期食管癌采用总D_T60Gy～70Gy／6～7周6MV－15MV－X线照射，同时采用经皮穿刺左支气管动脉、食管固有动脉或胃左动脉插管，沿导管灌注阿霉素、丝裂霉素、5氮脲嘧啶或鬼臼乙甙、顺铂等化疗药物，3－4周一次，2次一个疗程。同时选用工例仅用单纯放射治疗为同期对照。[结果]单纯疗组38例中CR＋PR共11例，有效率为28．9％；放疗合并动脉灌注化疗组36例中CR＋PR共16例，有效率为44．4％，两组比较放化组有效率明显高于单放组。两组病人随访18个月，单放组生存率为26．3％，放化组生存率为47．2％。而一年生存率放化组明显高于单放组。[结论]放疗合并动脉灌注化疗治疗中晚期食管癌疗效及生存期高于单纯放疗，值得临床进一步应用。
[Objective] To compare the clinical response, curative effect and survival time of arterial infusion chemotherapy combined with radiotherapy alone and radiotherapy for advanced esophageal cancer. [Methods] Thirty-six cases of advanced and advanced esophageal cancer confirmed by gastric pathology and pathology were treated with total D_T60Gy~70Gy/6~7 weeks 6MV-15MV-X line irradiation. Percutaneous puncture of left bronchial artery, esophageal proper artery or left gastric The arteries were cannulated and adriamycin, mitomycin, 5-nitrouracil, or gefitinib, cisplatin and other chemotherapeutic drugs were instilled along the catheter, once every 3-4 weeks, and once every two courses. At the same time, the selected workers were only treated with radiotherapy alone for the same period of time. [Results] In the simple treatment group, there were 11 cases of CR+PR in 28 cases, and the effective rate was 28.9%. In the group of arterial infusion chemotherapy combined with radiotherapy, there were 16 cases of CR+PR in the group, the effective rate was 44.4%. The efficiency is significantly higher than that of the single release group. After 18 months of follow-up in both groups, the survival rate was 26.3% in the radiotherapy group and 47.2% in the radiotherapy group. The one-year survival rate in the radiotherapy group was significantly higher than that in the radiotherapy group. [Conclusion] The efficacy and survival of radiotherapy combined with arterial infusion chemotherapy for advanced esophageal cancer were higher than that of radiotherapy alone. It is worthy of further clinical application.