A 400 km-long wide-angle seismic experiment along Lianxian-Gangkou profile in South China was carried out to study contact relationship between southeast continental margin of Yangtze block and northwest continental margin of Cathaysia block. We reconstructed crustal wide-angle reflection structure by the depth-domain pre-stack migration and the crustal velocity model constructed from the traveltime fitting. The wide-angle reflection section shows different reflection (from crystalline basement and Moho) pattern beneath the Yangtze and Cathaysia blocks,and suggests the Wuchuan-Sihui fault is the boundary between them. A cluster of well-developed reflections on Moho and in its underlying topmost mantle probably comes from al-ternative thin layers,which may be seismic signature of strong interaction between crust and mantle in the tectonic environment of lithosphere extension. A 400 km-long wide-angle seismic experiment along Lianxian-Gangkou profile in South China was carried out to study contact relationship between southeast continental margin of Yangtze block and northwest continental margin of Cathaysia block. We reconstructed crustal wide-angle reflection structure by the depth-domain pre-stack migration and the crustal velocity model constructed from the traveltime fitting. The wide-angle reflection section shows different reflection (from crystalline basement and Moho) pattern beneath the Yangtze and Cathaysia blocks, and suggests the Wuchuan-Sihui fault is the boundary between them. A cluster of well-developed reflections on Moho and in its underlying topmost mantle probably comes from al-ternative thin layers, which may be seismic signature of strong interaction between crust and mantle in the tectonic environment of lithosphere extension.