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目的探讨卡前列素氨丁三醇与缩宫素治疗宫缩乏力性产后出血的临床疗效。方法选择2008年1月—2015年2月收治的182例宫缩乏力性产后出血患者作为研究对象,随机分为对照组和观察组各91例。对照组采用缩宫素治疗,观察组采用卡前列素氨丁三醇联合缩宫素治疗。比较两组患者治疗效果、产后出血量及不良反应发生情况。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果观察组总有效率为94.51%,高于对照组的38.46%,差异有统计学意义(P<0.05)。观察组治疗后10、30 min出血量及总出血量、治疗后出血量分别为(56.1±13.1)、(78.3±12.4)、(421.0±71.0)、(101.2±15.3)ml,低于对照组的(156.0±23.5)、(253.1±13.1)、(610.2±85.1)、(289.0±22.7)ml,差异均有统计学意义(均P<0.05)。观察组不良反应发生率为7.7%,低于对照组的17.6%,差异有统计学意义(P<0.05)。结论在严格掌握适应证的情况下,采用卡前列素氨丁三醇与缩宫素治疗产后宫缩乏力性出血疗效好、不良反应小,使用方便,值得临床推广应用。
Objective To investigate the clinical efficacy of carboprost trometamol and oxytocin in the treatment of uterine inertia postpartum hemorrhage. Methods A total of 182 patients with uterine inertia postpartum hemorrhage admitted in our hospital from January 2008 to February 2015 were selected as study subjects and randomly divided into control group and observation group with 91 cases each. The control group was treated with oxytocin, and the observation group was treated with carboprost and oxytocin. The therapeutic effects, postpartum hemorrhage and adverse reactions were compared between the two groups. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The total effective rate in observation group was 94.51%, which was higher than that in control group (38.46%), the difference was statistically significant (P <0.05). The amount of bleeding and total bleeding at 10 and 30 min after treatment in the observation group were (56.1 ± 13.1), (78.3 ± 12.4), (421.0 ± 71.0) and (101.2 ± 15.3) ml, respectively, lower than those in the control group (156.0 ± 23.5), (253.1 ± 13.1), (610.2 ± 85.1) and (289.0 ± 22.7) ml respectively. There were significant differences between the two groups (all P <0.05). The incidence of adverse reactions in the observation group was 7.7%, lower than 17.6% in the control group, the difference was statistically significant (P <0.05). Conclusion In the strict indications of indications, the use of carboprost trometamol and oxytocin treatment of postpartum uterine bleeding is effective, small adverse reactions, easy to use, is worthy of clinical promotion and application.