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目的:对我院高效液相色谱-质谱联用(LC-MS/MS)法高通量筛查药物中毒224例回顾性分析,为临床中毒急救提供参考。方法:分别对224例病例的中毒发生年度、患者基本情况(性别、年龄),病例来源,中毒药物检出等情况进行统计分析。结果:3,5~7,11~12月为中毒高发期,中毒筛查患者以女性为主,比例约为男性的2倍,主要以药物中毒、药物自杀性中毒和食物中毒为主,检出药物以艾司唑仑、地西泮、咖啡因、替马西泮等镇静催眠药为主。结论:通过对我院中毒急救中心224例患者中毒性况回顾性分析,我们得到了多项具有临床指导意义和社会指导意义的结论。
OBJECTIVE: To retrospectively analyze 224 cases of drug poisoning by high-throughput LC-MS / MS in our hospital, and provide a reference for clinical emergency treatment. Methods: The annual incidence of poisoning in 224 cases, the basic information of the patients (sex, age), the source of cases and the detection of poisoning drugs were statistically analyzed. Results: From March to May, July to December, there was a high incidence of poisoning. Most of the patients with poisoning screening were female, accounting for about twice as much as men, mainly drug poisoning, drug suicide poisoning and food poisoning. Out of drugs to eszolam, diazepam, caffeine, temazepam and other sedatives mainly hypnotic. Conclusions: Through retrospective analysis of 224 cases of poisoning in our hospital emergency center, we got a number of conclusions with clinical significance and social guiding significance.