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目的观察小剂量美托洛尔对慢性肺心病心律失常的疗效,及其对肺通气功能的影响,评估慢性肺心病(COPD)患者对高选择性β-受体阻滞剂的用药有效性与安全性。方法缓解期或急性加重期待病情得到有效控制后的慢性肺心病,存在心律失常的患者,给口服美托洛尔6.25mg￣12.5mg,每12小时一次。于用药前和用药后14天分别作24小时动态心电图,观察心律失常变化;并于用药前及用药后14天和28天以后分别测定肺通气功能(FVC、FEV1.0、FEV1.0%、FEF25-75%、FEF75%),观察对肺通气功能的影响。结果小剂量美托洛尔对慢性肺心病心律失常治疗有效率为100%,而用药前后肺通气功能各观察指标差异均无显著性(P>0.05)。结论小剂量美托洛尔对慢性肺心病心律失常疗效确切,而对患者肺通气功能无明显影响,近期和长期用药均较为安全。
Objective To observe the curative effect of low-dose metoprolol on arrhythmia of chronic cor pulmonale and its effect on pulmonary ventilation, to evaluate the efficacy of high-selective beta-blockers in patients with chronic cor pulmonale (COPD) and safety. Method of remission or acute exacerbation Expected to be effective control of chronic pulmonary heart disease, patients with arrhythmia, oral metoprolol 6.25mg ~ 12.5mg, once every 12 hours. The changes of arrhythmia were observed 24 hours before and 14 days after treatment. Ventilation function (FVC, FEV1.0, FEV1.0%, FEV1.0) were measured before treatment and 14 days and 28 days after treatment, FEF25-75%, FEF75%), observe the impact of pulmonary ventilation. Results The low dose metoprolol treatment of chronic pulmonary heart disease arrhythmia effective rate of 100%, before and after treatment of pulmonary ventilation were no significant differences in the various indicators (P> 0.05). Conclusion Low-dose metoprolol has definite curative effect on arrhythmia of chronic pulmonary heart disease, but has no significant effect on pulmonary ventilation in patients. Both short-term and long-term use of metoprolol are safer.