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NAD-依赖性醛脱氢酶(ALDH)催化人体组织中几种醛的氧化。人肝脏中,ALDH主要有两种同工酶(Ⅰ和Ⅱ),其电泳、生物化学、催化特性以及亚细胞定位均不相同。同工酶Ⅰ在淀粉凝胶电泳中迁移偏向阳极,其pI值比同工酶Ⅱ低,并且对乙醛有较高的亲合力(Km值较低)。本研究发现大约50%的日本人在死后,肝
NAD-dependent aldehyde dehydrogenase (ALDH) catalyzes the oxidation of several aldehydes in human tissues. In human liver, ALDH mainly has two isoenzymes (Ⅰ and Ⅱ), which have different electrophoresis, biochemistry, catalytic properties and subcellular localization. Isoenzyme I migrated towards the anode during starch gel electrophoresis with a lower pI value than that of isozyme II and a higher affinity for acetaldehyde (lower Km value). This study found that about 50% of Japanese died after the liver