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目的观察多发性抽动症患儿血清S100B蛋白与健康同龄儿童是否存在差异及其临床意义。方法选择我院收治的多发性抽动症(TS)患儿164例(病例组),同期健康儿童98例(对照组),用酶联免疫吸附法(ELISA)检测TS患儿和健康儿童的血清S100B水平。结果正常及TS组儿童血清S100B浓度,随年龄的增大呈现下降趋势;TS患儿血清S100B与同龄组健康儿童相比显著升高(P<0.05);亚组分析,3~6岁组儿童,正常组与TS组S100B差别无统计学意义(P>0.05);而7~10岁组,11~14岁组,差别均有统计学意义(P<0.05)。结论血清S100B浓度呈年龄依赖型,且TS患儿水平高于同龄正常儿童。
Objective To observe the difference and clinical significance of serum S100B protein and healthy children of the same age with multiple tic disorder. Methods Totally 164 children with TS (TS) and 98 healthy children (control group) were enrolled in this study. The serum of TS children and healthy children were detected by enzyme-linked immunosorbent assay (ELISA) S100B level. Results Serum levels of S100B in TS children showed a decreasing trend with increasing age. Serum S100B levels in TS children were significantly higher than those in healthy children in TS group (P <0.05). In the subgroup analysis, children aged 3 to 6 years There was no significant difference between S100B group and TS group (P> 0.05). The difference was statistically significant between 7 and 10 years old group and 11 to 14 years old group (P <0.05). Conclusion Serum S100B concentration is age-dependent, and the level of TS children is higher than that of normal children of the same age.