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针对鼻咽癌细胞膜抗原制备了一株单克隆抗体（Ａｂ１），且又对该（Ａｂ１）可变区制备了一株单抗（Ａｂ２），此Ａｂ２能象鼻咽癌细胞膜抗原一样与Ａｂ１可变区的抗原结合位结合，因此在功能上Ａｂ２能够模拟原抗原，刺激机体的免疫系统。用该Ａｂ２对鼻咽癌放疗病人作主动免疫治疗，并设放疗加生理盐水注射对照组。检测了血清中人抗鼠抗体（ＨＡＭＡ）的产生情况，并检测了治疗前后各项体液免疫指标，包括抗Ａｂ２抗体（Ａｂ３）和抗鼻咽癌细胞抗体（Ａｂ１）水平以及各项细胞免疫指标，包括血清中细胞因子ＴＮＦ－α、ＩＬ－２、ＩＦＮ－γ的水平和外周血单个核细胞（ＰＢＭＣ）ＩＬ－２ｍＲＮＡ的表达。结果表明，与对照组相比，鼻咽癌抗独特型抗体能使鼻咽癌放疗病人的免疫指标上升，有增强免疫功能的作用，可能是一种有益的辅助疗法。
A monoclonal antibody (Ab1) was prepared against the membrane antigen of nasopharyngeal carcinoma cells, and a monoclonal antibody (Ab2) was prepared against the variable region of (Ab1). This Ab2 can be similar to Ab1 as a membrane antigen of nasopharyngeal carcinoma cells. The antigen-binding site of the variable region binds, so Ab2 can functionally mimic the original antigen and stimulate the body’s immune system. The Ab2 was used for active immunotherapy of patients with nasopharyngeal carcinoma radiotherapy, and radiotherapy plus saline injection control group was set up. The production of human anti-mouse antibody (HAMA) in serum was detected, and various humoral immune indicators before and after treatment were detected, including anti-Ab2 antibody (Ab3) and anti-nasopharyngeal cell antibody (Ab1) levels and various cellular immune indices. , including serum levels of cytokines TNF-α, IL-2, IFN-γ and peripheral blood mononuclear cells (PBMC) IL-2 mRNA expression. The results showed that compared with the control group, nasopharyngeal carcinoma anti-idiotypic antibody can increase the immune index of patients with nasopharyngeal carcinoma radiotherapy, there is a role in enhancing immune function, may be a useful adjuvant therapy.