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目的探讨酮替芬联合孟鲁司特钠治疗小儿支气管炎的临床疗效。方法选取万年县人民医院2015年6月—2016年5月收治的支气管炎患儿98例,根据随机数字抽签法分为对照组和研究组,各49例。对照组患儿给予孟鲁司特钠治疗,研究组患儿在对照组基础上给予富马酸酮替芬片治疗,两组患儿均持续治疗15 d。比较两组患儿的临床疗效,临床症状消失时间(咳嗽消失时间、肺部哮鸣音消失时间、体温恢复正常时间、干湿啰音消失时间)及不良反应发生情况。结果研究组患儿临床疗效优于对照组(P<0.05)。研究组患儿咳嗽消失时间、肺部哮鸣音消失时间、体温恢复正常时间及干湿啰音消失时间短于对照组(P<0.05)。研究组患儿不良反应发生率低于对照组(P<0.05)。结论孟鲁司特钠联合酮替芬治疗小儿支气管炎临床疗效确切,可快速缓解患儿的临床症状,且不良反应少,安全性好。
Objective To investigate the clinical efficacy of ketotifen combined with montelukast sodium in the treatment of pediatric bronchitis. Methods Ninety-eight children with bronchitis admitted from June 2015 to May 2016 in Wannian County People’s Hospital were divided into control group and study group according to random number drawing method. Children in the control group were given montelukast sodium. The children in the study group were treated with ketotifen fumarate on the basis of the control group, and both children were treated for 15 days. Clinical efficacy, clinical symptoms disappear time (cough disappear time, lung wheeze disappear time, body temperature recovery time, dry wet rales disappear time) and adverse reactions were compared between the two groups. Results The clinical efficacy of study group was better than that of control group (P <0.05). The study group cough disappear time, pulmonary wheeze disappear time, body temperature recovery time and the disappearance of wet and dry rales shorter than the control group (P <0.05). The incidence of adverse reactions in study group was lower than that in control group (P <0.05). Conclusion Montelukast combined with ketotifen treatment of children with bronchitis clinical curative effect, can quickly relieve the clinical symptoms in children with less adverse reactions, good safety.