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本实验采用ＦｅＳＯ＿４／抗坏血酸体系观察了氧自由基对大鼠心肌线粒体质子ＡＴＰ酶（Ｈ￣＋－ＡＴＰａｓｅ）水解与合成活性的损伤作用及丹参素（ＤＳ－１８２）的保护作用效应。结果表明：ＦｅＳＯ＿４／抗坏血酸体系产生的氧自由基可使线粒体Ｈ￣＋－ＡＴＰａｓｅ水解活性明显升高、合成活性明显下降，丹参素可以防止Ｈ￣＋－ＡＴＰａｓｅ水解活性升高，合成活性下降、显示出良好的保护作用。
In this experiment, FeSO 4 /ascorbic acid system was used to observe the effects of oxygen free radicals on the damage of myocardial mitochondrial proton ATPase (H ̄ +-ATPase) hydrolysis and synthesis activity and the protective effect of Danshensu (DS-182). The results showed that the oxygen free radicals produced by the FeSO4/ascorbic acid system can significantly increase the hydrolytic activity of mitochondrial H~+-ATPase and decrease the synthesis activity. Danshensu can prevent the hydrolysis activity of H~+-ATPase from increasing, and its synthesis activity is decreased. Good protection.