某医药研究所药物合成室,自1990年10月开始合成氟哌酸中间体——二氧基甲叉丙二酸二乙酯以来,三位工作人员均不同程度地发生了接触性皮炎。现将劳动卫生学调查情况及典型病例报告如下:现场劳卫学调查合成反应过程:原甲酸三乙酯(下简称原酯)+丙二酸二乙酯(下简称丙酯)(氧化锌、乙酸酐)/(150℃,4小时)→二氧基甲叉 A pharmaceutical research institute of pharmaceutical synthesis room, starting in October 1990 synthesis of norfloxacin intermediate - di-methyl-2-oxometalate since the three workers have varying degrees of contact dermatitis. Now the labor hygiene survey and case reports are as follows: On-site investigation of labor and health synthesis process: triethyl orthoformate (hereinafter referred to as the original ester) + diethyl malonate (hereinafter referred to as propyl ester) (zinc oxide, Acetic anhydride) / (150 ° C, 4 hours) → dioxymethylene