论文部分内容阅读
大肠癌的确切发病机制仍不清楚,近年来研究多集中在癌基因及抑癌基因方面。癌基因的激活、抑癌基因的失活及其他基因的突变导致细胞克隆性增殖而癌变。大肠癌常见抑癌基因有p53、p16、p73、p21、APC、MCC、DCC、nm23、DPC4、ING1、KAI1、MKK4、PTEN、BRCA1、WWOX、HSU17714、STK11、CHD5、TIP30等,本文就上述代表性基因的研究进展进行综述。
The exact pathogenesis of colorectal cancer remains unclear. In recent years, most studies focused on oncogenes and tumor suppressor genes. Activation of oncogenes, inactivation of tumor suppressor genes and mutations in other genes lead to cell clonal proliferation and carcinogenesis. The common tumor suppressor genes of colorectal cancer include p53, p16, p73, p21, APC, MCC, DCC, nm23, DPC4, ING1, KAI1, MKK4, PTEN, BRCA1, WWOX, HSU17714, STK11, CHD5 and TIP30. Sexual gene research progress are reviewed.