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万古霉素(vancomycin)是糖肽类抗生素。常用于抗革兰氏阳性菌,包括抗甲氧西林(me-thicillin)的葡萄球菌。病人在治疗时为保证达到治疗浓度并避免耳中毒和肾中毒,需要监测血中的万古霉素水平。本文介绍改良的HPLC法定量测定血浆和组织中的万古霉素量。样品中的万古霉素使用...
Vancomycin is a glycopeptide antibiotic. Commonly used against gram-positive bacteria, including methicillin-resistant staphylococci. Patients are monitored for vancomycin levels in order to achieve therapeutic concentrations and avoid ototoxicity and nephrotoxicity during treatment. This article describes a modified HPLC method for the quantitative determination of vancomycin levels in plasma and tissue. Vancomycin in the sample is used ...