本文报告用L-门冬酰胺酶治疗20例儿童急性白血病,其中19例为急淋,1例为急单,年龄4～14岁,病程6月～4年,都是第2～4次急性发作,这些患儿已长期应用各种细胞抑制剂(6巯基嘌呤、氨甲喋呤,长春新碱、柔毛霉素、环磷酰胺)和强的松龙,并且都对这些药物产生了抗药性。在采用酶治疗 This article reports the use of L-asparaginase in the treatment of 20 children with acute leukemia, of which 19 cases of acute lymphoblastic, one case of emergency orders, aged 4 to 14 years, duration of 6 months to 4 years, are 2 to 4 times the acute These children have long been exposed to various cytostatics (6-mercaptopurine, methotrexate, vincristine, daunomycin, cyclophosphamide) and prednisolone, all of which are resistant to these drugs. In the use of enzyme therapy