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目的了解住院患者腰椎骨密度(T-score)与激素的相关性。方法选取2013年3月~2016年3月在解放军181医院老年病科住院的患者290例,年龄38~97岁,平均年龄(77.5±13.7)岁。对腰椎骨密度与不同性别患者及患者各年龄组多种激素进行偏相关分析,并对骨质正常组、骨量减少组、骨质疏松(OP)组的激素水平进行比较。结果腰椎T-score与激素偏相关分析:男性与体重、睾酮(TESTO)、C肽(C-P)相关,女性与年龄、身高、体重、游离雌三醇(f E3)、三碘甲状腺原氨酸(T3)相关;年轻老年人组、高龄老年人组腰椎T-score与性别、体重有关,与年龄均不相关;年轻老年人组腰椎T-score与身高相关;所有老年人腰椎T-score均与雌二醇(E2)、C-P相关;高龄老年人组腰椎T-score均与游离三碘甲状腺素(FT3)有关;年轻老年人组股骨骨密度T-score与甲状腺素(T4)、甲状旁腺激素(PTH)相关(P<0.05)。男性激素与女性比较,TESTO、E2、f E3、T3、T4、生长激素(GH)、C-P等差异均有统计学意义(P<0.05);OP、骨量减少、骨质正常组3组比较,性别、年龄、身高、体重、E2、C-P差异均有统计学意义(P<0.05)。骨质正常组与骨量减少组比较,性别、身高、体重差异均有统计学意义(P<0.05),骨量减少组与骨质疏松组比较,只有体重差异有统计学意义(P<0.05),骨质正常组与骨质疏松组比较,性别、身高、体重、TESTO、E2、FT4、C-P差异均有统计学意义(P<0.05)。结论腰椎骨密度与老年人的性别、体重相关,与年轻老年人组身高相关。所有老年人组腰椎骨密度与E2、C-P相关,部分老年人腰椎骨密度与FT3、T4、PTH相关;骨质正常与骨质疏松组比较,女性、身材高、体重轻、TESTO、E2、C-P减少均对骨质疏松有影响。
Objective To understand the relationship between lumbar spine bone mineral density (T-score) and hormones in hospitalized patients. Methods From March 2013 to March 2016, 290 patients were hospitalized in Department of Geriatrics, People’s Liberation Army 181 Hospital, aged from 38 to 97 years with an average age of 77.5 ± 13.7 years. The partial correlation analysis of lumbar bone mineral density with different gender and age and gender of patients were conducted. The levels of hormones in normal bone mass group, osteopenia group and osteoporosis group were compared. Results The correlation analysis of lumbar T-score with hormone: The correlation between male and body weight, testosterone (TESTO), C peptide (CP), and age, height, weight, free estriol (f E3), triiodothyronine (T3). The scores of lumbar spine T-score were related to gender and body weight in young and old people, but not in age. T-score in lumbar spine of young and old people was related to height. (P <0.05). The T-score of the lumbar vertebra in the elderly was related to free triiodothyronine (FT3). The femoral BMD T-score in the elderly group was significantly higher than that in the thyroxine (T4) PTH (P <0.05). There was significant difference between male hormone and female in TESTO, E2, f E3, T3, T4, GH and CP (P <0.05); OP, osteopenia and normal group There were significant differences in gender, age, height, weight, E2 and CP (P <0.05). There were significant differences in gender, height and weight between the normal bone mass group and the osteopenia group (P <0.05). Only the body weight difference between the osteopenia group and the osteoporosis group was statistically significant (P <0.05 ). There were significant differences in gender, height, weight, TESTO, E2, FT4 and CP between normal bone group and osteoporosis group (P <0.05). Conclusions Lumbar bone mineral density is related to the gender and weight of the elderly and is related to the height of the young group. BMD of lumbar vertebra was related to E2 and CP in all the elderly group, and BMD of lumbar vertebra in some elderly was related to FT3, T4 and PTH. Compared with osteoporosis group, females, tall, light weight, TESTO, E2, CP Reduce the impact of osteoporosis.