目的制备一种具有结晶形态的利福布丁。方法以无定形利福布丁为原料,采用正己烷或者正己烷与羧酸酯的混合物为溶剂,通过梯度降温法制备具有结晶形态的利福布丁。结果首次制备得到了具有结晶形态的利福布丁,并命名为利福布丁晶型Ⅰ。结论通过选择适当的溶剂和结晶方法,可以将无定形利福布丁制备成为具有结晶形态的利福布丁,这种具有结晶形态的利福布丁流动性好、稳定性高。 Objective To prepare a rifampicin with crystalline morphology. Methods The amorphous rifabutin was used as raw material, and the mixture of n-hexane or n-hexane and carboxylic acid ester was used as solvent to prepare rifabutin with crystal form by gradient cooling method. The results obtained for the first time with a crystalline form of rifabutin, and named rifabutin crystal form Ⅰ. Conclusion Amorphous rifabutin can be made into rifabutin in a crystalline form by selecting the appropriate solvent and crystallization method. This rifampicin with a crystalline form has good fluidity and high stability.