In regards to the earthquakes recording M ≥ 5.0 that occurred in middle northern part of the Qinghai-Xizang (Tibet) Block from 1970 ～ 2003, in this study we describe the temporal and spatial centralization features of the weak earthquakes and the enhancement and anomalous quiescence of their seismic activity before main shocks through 4 parameters, which are basically not correlated: earthquake time centralization degree parameter Ct, earthquake space centralization degree parameter Cd, η value and weak earthquake frequency and so on. On the basis of calculation results, it has been seen that before earthquakes with M ≥ 5.0 took place in the middle northern part of the Qinghai-Xizang (Tibet) Block, the frequency of weak earthquakes often shows ascent and drop, their strength shows an obvious enhancement and the centralization distribution with time and space is evident.