论文部分内容阅读
目的观察5-氨基酮戊酸光动力疗法治疗鲍温病的临床疗效。方法将20例鲍温病患者分为两组,各10例。治疗组予5-氨基酮戊酸外涂于皮损处,3h后予红光照射20min,能量密度100～120J/cm2,1次/周,共4周。对照组外涂5-氟尿嘧啶软膏皮损处,2次/d,共4周。结果治疗组完全缓解率为90.00%,对照组为30.00%,两组间完全缓解率比较,差异有统计学意义(P<0.05)。且治疗组均未见严重不良反应,对照组有溃疡及瘢痕等不良反应。结论 5-氨基酮戊酸光动力疗法治疗鲍温病临床疗效较好,且无严重不良反应,值得临床推广应用。
Objective To observe the clinical efficacy of 5-aminolevulinic acid photodynamic therapy in the treatment of Bowen’s disease. Methods 20 cases of Bowen’s disease were divided into two groups, 10 cases each. In the treatment group, 5-aminolevulinic acid was applied to the skin lesion and irradiated with red light for 3 hours and energy density of 100-120 J / cm2 for one week / week for 4 weeks. The control group was coated with 5-fluorouracil ointment lesions, 2 times / d, a total of 4 weeks. Results The complete remission rate was 90.00% in the treatment group and 30.00% in the control group. There was significant difference in the complete remission rate between the two groups (P <0.05). And the treatment group had no serious adverse reactions, the control group had ulcers and scars and other adverse reactions. Conclusion 5-aminolevulinic acid photodynamic therapy for Bowen’s disease has a good clinical efficacy, and no serious adverse reactions, worthy of clinical application.