目的　研究肿瘤坏死因子（Ｔｕｍｏｒ Ｎｅｃｒｏｓｉｓ Ｆａｃｔｏｒα，ＴＮＦα） 对幽门螺杆菌（ Ｈｅｌｉｃｏｂａｃｔｅｒ ｐｙｌｏｒｉ，Ｈｐ） 感染患者胃泌素（Ｇｓｔｒｉｎ，Ｇａｓ）产生的影响。方法　采用组织培养技术和放射免疫检测技术测定Ｈｐ 感染患者胃窦粘膜培养上清液中Ｇａｓ 的分泌水平及ＴＮＦα对其产生的影响。结果　Ｈｐ 阳性患者的胃窦Ｇａｓ 水平显著高于对照组和Ｈｐ 阴性患者；合并活动性胃炎者Ｈｐ 阳性率和Ｇａｓ 含量均显著高于非活动性胃炎者。ＴＮＦα与Ｈｐ 阳性或Ｈｐ 阴性患者胃窦粘膜共同孵育后可明显增加粘膜Ｇａｓ 含量，并呈量效关系。结论　ＴＮＦα可促使胃窦粘膜Ｇａｓ 的产生，这可能是Ｈｐ 感染导致胃肠粘膜损害的一个环节。 Objective To study the effect of Tumor Necrosis Factorα (TNFα) on the production of gastrin (Gstrin, Gas) in patients with Helicobacter pylori (Hp) infection. Methods Tissue culture technique and radioimmunoassay technique were used to determine the secretion of Gas in gastric antrum mucosa culture supernatant from patients with Hp infection and the effect of TNFα on it. Results Gastric gastric Gas levels in Hp positive patients were significantly higher than those in controls and Hp negative patients. The positive rate of Hp and Gas in patients with active gastritis were significantly higher than those in inactive gastritis patients. TNF  α and Hp-positive or Hp-negative patients with antral gastric mucosa incubation can significantly increase mucosal Gas content, and the dose-response relationship. Conclusion TNF  α can promote gas production of gastric mucosa, which may be Hp infection lead to gastrointestinal mucosal damage as a link.