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目的:通过动物实验的方法观察并分析川贝雪梨膏的主要药效。方法:分别使用氨水引咳法、豚鼠整体平喘实验、大鼠毛细管排痰实验、小鼠耳廓肿胀实验来对川贝雪梨膏的镇咳、平喘、祛痰及抗炎效用进行实验观察及分析。结果:实验表明,川贝雪梨膏具有较为明显的镇咳、平喘作用,其对小鼠咳嗽潜伏期的延长作用较强;大鼠毛细管排痰实验表明该药可促进痰液的排除;小鼠耳廓肿胀实验表明对由药物(二甲苯)引起的耳廓肿胀在应用本药后可受到明显抑制。结论:川贝雪梨膏可以较为显著地延长实验动物的咳嗽潜伏期,松弛其呼吸道平滑肌,减轻及抑制炎性反应并促进痰液的排出,本药的镇咳、平喘、祛痰及抗炎作用较为明显,应在今后加以进一步研究。
Objective: To observe and analyze the main efficacy of Chuanbei Xueli Paste through animal experiments. Methods: The antitussive, antiasthmatic, expectorant and anti-inflammatory effects of Chuanbei Xueli Paste were tested by ammonia cough-inducing method, guinea pig general anti-asthma experiment, rat capillary expectoration experiment and mice ear auricle swelling test respectively And analysis. Results: Experiments show that Chuanbei Xueli paste has a more obvious antitussive and antiasthmatic effect, which has a stronger effect on prolonging the latent period of cough in mice. Excessive sputum excretion in rats shows that the drug can promote sputum elimination; mice Ear auricle swelling experiments show that by the drug (xylene) caused by auricle swelling in the application of this medicine can be significantly inhibited. Conclusion: Chuanbei Xueli paste can significantly prolong the latent period of cough, relax the respiratory smooth muscle, relieve and inhibit the inflammatory reaction and promote the discharge of sputum. The antitussive, antiasthmatic, expectorant and anti-inflammatory effects More obvious, should be further studied in the future.