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为探讨抗组胺剂、减充血剂对儿童渗出性非化脓性中耳炎(OME)的作用及儿童OME的自然病史,作者应用双盲法,并用安慰剂作为对照,对74例OME儿童做了长达12周的随访观察。受试儿童均符合下列条件,6月～10岁,随访前已用标准剂量的抗生素治疗,经鼓气耳镜检查证实鼓膜异常,鼓室压图异常,可确诊为OME者。唇裂、腭裂、慢性消耗病、免疫缺陷病、曾用皮质类固醇及双侧听力损失大于25dB或单侧大于35dB者均不作为受试对象。受试儿童均由一位医师做听力检查,2岁以上者用纯音测听法,2岁
To investigate the role of antihistamines and decongestants in the treatment of childhood exudative non-suppurative otitis media (OME) and the natural history of childhood OME, the authors used a double-blind approach with placebo as a control and performed 74 children with OME Up to 12 weeks of follow-up observation. The children under test all met the following criteria. From June to 10 years old, they had been treated with the standard dose of antibiotics before the visit, and the tympanic membrane abnormalities were confirmed by electrosurgical otoscopy. The tympanogram was abnormal and could be diagnosed as OME. Cleft lip, cleft palate, chronic wasting disease, immunodeficiency disease, corticosteroids and bilateral hearing loss greater than 25dB or unilateral greater than 35dB were not as subjects. Children under test by a physician to do hearing tests, 2 years of age with pure tone audiometry, 2 years old