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为观察牛磺酸对肝脏缺血再灌注损伤的保护作用，建立SD大鼠肝缺血再灌注模型，将大鼠分成5组，分别于缺血前经外周静脉、门静脉注入个碳酸及再灌注前经门静脉注入牛磺酸，及假手术组对照组。结果表明，缺血前给牛磷酸组具有抑制缺血再灌注时肝细胞内酶的漏出，降低肝组织内丙二醇（MDA）含量，提高超氧化歧化酶（SOD）、过氧化氢酶（Cat）、谷胱甘肽过氧化物酶（GSH－PX）、Na+，K+－ATP酶及Ca2+－ATP酶活力，抑制细胞及线粒体内Ca2+的蓄积，再灌注后2／小时上述各指标与对照组比较均有显著差异（P＜005）。本研究结果提示：牛磺酸具有较强的抗肝脏缺血再灌注损伤，保护肝细胞功能的作用。
To observe the protective effect of taurine on hepatic ischemia-reperfusion injury in rats, a model of hepatic ischemia-reperfusion in SD rats was established. The rats were divided into 5 groups and injected with carbonic acid and reperfusion Taurine before portal vein injection, and sham operation group control group. The results showed that pre-ischemic bovine phosphate group could inhibit the leakage of intrahepatic enzymes during ischemia-reperfusion, decrease the content of MDA and increase the activity of superoxide dismutase (SOD), catalase (Cat) , Glutathione peroxidase (GSH-PX), Na +, K + -ATPase and Ca2 + -ATPase activity, inhibited the accumulation of Ca2 + in cells and mitochondria, 2 / h after reperfusion compared with the control group There were significant differences (P <005). The results suggest that: taurine has a strong anti-hepatic ischemia-reperfusion injury, the role of protecting liver cell function.