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目的:探讨系统性红斑狼疮(SLE)患者血清25羟基维生素D3水平与实验室相关指标的关系.方法:用酶联免疫法检测42例SLE患者及30例体检健康者血清25羟基维生素D3水平,并与自身抗体和免疫球蛋白(IgG、IgA、IgM)、补体3(C3)、补体4(C4)进行比较分析.结果:SLE组患者血清25羟基维生素D3水平明显低于健康对照组(P＜0.05);SLE组患者ANA高滴度亚组及低滴度亚组之间,抗Sm抗体阳性与阴性之间,25羟基维生素D3水平比较差异无统计学意义(P＞0.05);抗ds-DNA抗体阳性组25羟基维生素D3水平明显低于抗ds-DNA抗体阴性组(P＜0.05);SLE组25羟基维生素D3水平与IgG、SLEDAI评分呈明显负相关,与C3呈明显正相关,而健康对照组25羟基维生素D3与各指标无明显相关性.结论:SLE患者血清25羟基维生素D3水平明显下降,与抗ds-DNA抗体和疾病活动程度密切相关.检测25羟基维生素D3对SLE诊疗有重要的临床应用价值.“,”Objective:To investigate the relationship between serum 25-hydroxyvitamin D3 and related laboratory parameters in patients with systemic lupus erythematosus (SLE).Method:Forty-two patients with SLE and 30 healthy subjects were enrolled in this study.Serum levels of 25-hydroxyvitamin D3 were detected by enzymelinked immunosorbent assay (ELISA).Serum levels of 25-hydroxyvitamin D3 were measured with autoantibodies and immunoglobulins (IgG,IgA,IgM),complement 3 (C3),complement 4 (C4) for comparative analysis.Result:The level of serum 25-hydroxyvitamin D3 was significantly lower in patients with SLE than that in healthy controls (P＜0.05).The level of serum 25 hydroxy vitamin D3 was not significantly different between high-titer group and low-titer group with ANA and between positive group and negative group with anti-Sm-antibody in patients with SLE.The level of 25 hydroxy vitamin D3 in positive group of anti-dsDNA antibody was significantly lower than that in negative group of anti-dsDNA antibody(P＜0.05).The level of 25 hydroxy vitamin D3 in patients with SLE was negatively correlated with IgG and the SLEDAI score and was positively correlated with C3.While in the healthy control group the level of 25 hydroxy vitamin D3 and each index had no significant correlation.Conclusion:Serum 25-hydroxyvitamin D3 levels in SLE patients were significantly decreased,which were closely related to the anti-dsDNA antibody and disease activity.Detection of 25 hydroxy vitamin D3 SLE diagnosis and treatment has important clinical value.