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裸鼠虽然缺乏细胞介导的免疫反应,即缺乏免疫监视功能,但自发性肿瘤却不多见。Rygaad等观察了6,900只BALB/C系裸小鼠,未发现一例自发性肿瘤。根据Shimosato等的资料,在309只BALB/C系裸鼠中,肺腺瘤的发生率为1.9％,淋巴瘤为1.9％,乳癌和胆管癌各占0.4％。最近,我们在新导入的ICR/PBI系裸小鼠中,发现一例罕见的原发性肝淋巴肉瘤。病料 ICR/PBI-un系裸小鼠,为一株新导入系裸鼠,第2次回交,(?)性,6月龄。由中国药品生物制品检定所引入,在SPF条件下饲养。该裸鼠一个月来日逐消瘦,腹部膨大。血涂片可见少数晚幼红细胞,未见瘤细胞。经扑杀作病理学检查,发现肝脏有多发
Although nude mice lack a cell-mediated immune response, ie lack of immune surveillance, spontaneous tumors are rare. Rygaad et al. observed 6,900 BALB/C nude mice and found no spontaneous tumors. According to Shimosato et al., in 309 BALB/C strain nude mice, the incidence of lung adenoma was 1.9%, lymphoma was 1.9%, and breast cancer and cholangiocarcinoma each accounted for 0.4%. Recently, we discovered a rare case of primary hepatic lymphosarcoma in newly introduced ICR/PBI nude mice. Disease ICR/PBI-un was nude mice, a new line of nude mice, the second backcross, (?) sex, 6 months of age. Introduced by China National Institute for the Control of Pharmaceutical and Biological Products and kept under SPF conditions. The nude mouse leans and loses weight every day for a month and the abdomen expands. A few smears of red blood cells were seen on the blood smears, and no neoplastic cells were observed. After culling for pathological examination, it was found that the liver had multiple